isohemagglutination是什么意思，isohemagglutination翻译

isohemagglutination是什么意思，isohemagglutination翻译

Isohemagglutination is a term used to describe the phenomenon where red blood cells (RBCs) clump together in the presence of certain antibodies, but without the presence of complement. This process is similar to agglutination, which occurs when RBCs clump together in the presence of both antibodies and complement. However, isohemagglutination is specifically refers to the clumping of RBCs in the absence of complement.

Isohemagglutination can occur in various clinical settings, including the diagnosis of autoimmune disorders and the detection of certain infections. In autoimmune disorders, the body's immune system mistakenly attacks its own RBCs, leading to the production of antibodies that can cause isohemagglutination. This can be useful in diagnosing conditions such as autoimmune hemolytic anemia, where the immune system produces antibodies against its own RBCs, leading to their destruction.

Infections can also lead to isohemagglutination. Certain pathogens, such as bacteria and viruses, can stimulate the production of antibodies in the body that can cause clumping of RBCs. This can be detected using isohemagglutination tests, which can help in diagnosing infections and monitoring the effectiveness of treatment.

One example of a test that uses isohemagglutination is theWidal test, which is used for the serological diagnosis of Salmonella enterica serovar Typhi infection, the causative agent of typhoid fever. In this test, patient serum is mixed with specific antisera against Salmonella Typhi O and H antigens, followed by the addition of RBCs. If the patient has antibodies against these antigens, the RBCs will clump together, indicating a positive result for typhoid fever.

Isohemagglutination can also be used in the production of diagnostic reagents and vaccines. By using isohemagglutination techniques, researchers can study the specificity of antibodies and develop tests that can accurately detect and diagnose certain diseases.

In summary, isohemagglutination is a process where RBCs clump together in the presence of certain antibodies, but without the presence of complement. This phenomenon can be useful in diagnosing autoimmune disorders, detecting infections, and producing diagnostic reagents and vaccines. TheWidal test is an example of a test that uses isohemagglutination for the diagnosis of typhoid fever.